Online cleaning technology for pharmaceutical and food industries

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1, ultrasonic cleaning technology

Ultrasonic cleaning technology is widely used in the pharmaceutical industry. The main principle is to use the ultrasonic wave propagation speed to produce a speed difference with the change of the medium, thereby forming shear stress at the interface, resulting in weakening of the bonding force between molecules and molecules, between the molecules and the tube wall, preventing the scale crystal from adhering to the tube. On the wall or on the wall. The strong pressure generated by the cavitation of the ultrasonic wave in the fluid medium accelerates the precipitation of Ca2+ and Mg2+, and can crush the precipitated carbonate scale and particulate impurities into fine particles and suspend in the medium. The high temperature and high pressure special physical environment created by the ultrasonic wave in the fluid will accelerate the chemical reaction to change the scale condition of the scale. Therefore, the ultrasonic CIP anti-scaling technology has risen rapidly, and the cleaning effect has been well received.

2, dry ice cleaning technology

Dry ice cleaning technology originated in the United States. It uses dry ice granules as a spray medium to clean all kinds of stubborn oils and mixed deposits, and has achieved good results. It is a new type of cleaning technology. In the 1980s, with the increasing miniaturization and low cost of dry ice production equipment, dry ice cleaning technology was continuously recognized by industrial users and was widely used in various fields.

The dry ice blasting washing machine has been improved, the injection pressure has dropped from the original 1.14 MPa to the current 0.15 MPa, and the original double-tube injection has been changed to single-tube injection. The new nozzle technology makes the equipment quick and compact, and the equipment is easy to use and economical. Sexuality and cleaning effect are significantly improved, bringing practical benefits to users.

ColdJet is a leader in this field and dry ice cleaning is now widely used in various industries in the United States. The application of developed countries such as Europe and Japan is also very common. Germany, Switzerland, Denmark, the United Kingdom, Italy and other countries have strong dry ice cleaning enterprises. China's dry ice cleaning technology began in the 1990s.

Dry ice cleaning technology can be applied to food and medicine fields in addition to its wide application in industrial, chemical and service industries. In the food and beverage industry, dry ice CIP technology has unparalleled superiority in removing the dirt imported from the conveyor belts, furnaces, baking trays, rollers and conveyors. AnheuserBusch.Inc., BlueBellCreamery, FritoLay and other alcohol and food companies have adopted dry ice cleaning technology. Danish well-known beer producers Carlsberg and Tuborg, Italy's Nutella are introducing dry ice cleaning technology into the production process to achieve online automatic cleaning; in the field of medicine, dry ice cleaning technology has the advantages of safety and environmental protection (such as dry, non-toxic, low temperature sterilization) Etc.), the entire production process of NovoNordisk Pharmaceuticals uses dry ice cleaning technology.

Dry ice cleaning equipment is mainly divided into two components. The first is dry ice production equipment, and the second is dry ice jet cleaning machine.

The dry ice production equipment is usually made of liquid carbon dioxide as a raw material. It is sprayed into the collection chamber through a throttling nozzle driven by a cryogenic liquid pump. A part of the liquid carbon dioxide is instantaneously vaporized, and the other part becomes a snowflake solid particle, which is squeezed by a molding die. Pressed to form a variety of different pieces of granular or granular dry ice. In the dry ice cleaning, cylindrical dry ice particles having a diameter of 3 mm and a length of 5 to 10 mm are usually used.

The dry ice blasting washing machine uses 0.15 MPa and a clean compressed air with a flow rate of 2 m3/min or more as a power source. Through the mechanical feeding system, the dry ice granules are evenly transported into the air injection pipe, and accelerated by mixing with the air in the pipe. Finally, at a speed of 2 to 3 Mach, the working surface is impacted to achieve the purpose of cleaning, as shown in FIG. When it is sprayed onto the surface of the object at a high speed, the impact kinetic energy instantaneously vaporizes the dry ice particles, and absorbs a large amount of heat, causing intense heat exchange on the cleaning surface, forcing the attachment to quench and shrink, embrittlement, and usually attached matter and substrate. The material has different expansion coefficients, and the temperature difference between the surface layer and the inside will break the bond between the two materials. The instantaneous rapid shrinkage can tear the non-structural connection, and the dry ice will suddenly increase in volume during the gasification process of a few thousandths of a second. 800 times, this will cause a "micro explosion" at the impact point, effectively knocking down the attachments, and after the gasification, the dry ice becomes carbon dioxide gas, no residue, no waste. It can be seen that the dry ice cleaning has unique thermal effects and mechanical effects, especially when the object to be cleaned has a higher temperature in the on-line state, or the attachment has obvious cold brittleness.

Because dry ice has a disinfecting effect, the surface of the object after cleaning becomes a "clean surface". Therefore, as a kind of disinfection cleaning, it can also be used as the last cleaning before product packaging. Its application in the production of food and pharmaceutical products has a huge potential market, which should be given attention and development.

Since the dry ice particles only leave the cleaned dirt after cleaning, the dry ice particles have been vaporized into carbon dioxide gas, and there is no other chemical residue, which does not pollute the environment, and the conventional detergent cleaning causes secondary pollution to the water body and the environment. In foreign countries, dry ice cleaning technology has received a series of safety approvals, in line with the US Department of Agriculture (USDA), Food and Drug Administration (FDA), Environmental Protection Agency (EPA) safety requirements. It can be used in the food and hygiene industry without chemical damage to the practitioners. It is an ideal substitute for chemical cleaners.


3. Chemical cleaning technology

The chemical cleaning technology refers to the method of using the chemical cleaning agent to dissolve the dirt, the dissolution and scouring action of the water, the temperature effect, cleaning the inner surface of the container equipment and the pipeline, and meeting the process requirements, thereby realizing the CIP method. By washing, it is possible to remove precipitates of residual products, proteins, resins, oils, etc., and remove organic and inorganic salts and microorganisms on the surface of the container to achieve a certain degree of cleanliness. It can be said that chemical CIP technology is currently the mainstream cleaning technology for medical engineering.

The chemical CIP system mainly includes a cleaning agent station (washing sterilization liquid preparation and storage), a circulation adjustment system (transfer pump, recovery pump, piping and valves), a control system, and an execution system (canister).

4, high pressure water jet cleaning technology

Water jet cleaning technology is still irreplaceable in the food and pharmaceutical industry. Therefore, improving existing water jet cleaning processes and equipment has realistic economic significance.

The main directions of improvement include: (1) Improvement of the water jet cleaning nozzle. Water jet cleaning relies mainly on its high-speed impact. The nozzle converts the pump's (static) pressure into speed, which is the most critical component in the water jet cleaning process. At present, the difference in nozzle quality between domestic and foreign is mainly reflected in the manufacturing materials and processing technology of the nozzle. In order to improve nozzle performance and reduce energy consumption, fluid mechanics theory and processing technology can be combined to improve nozzle performance; (2) development of water-saving and energy-saving water jet technology. Since the water consumption and energy consumption of water jets are too large, the development of water-saving and energy-saving water jet technology is an inevitable trend of development.