300kg/batch wet granulator 1. The wet granulator highly satisfies the height of the wet granulator connected below and used in connection with the boiling granulator. 2. The inverted cone design of the pot body is equipped with a vacuum feeding system; 3, negative pressure vacuum continuous feeding, 20 ~ 30Kg / min, two-stage filter dust collector; silo, bellows, etc. are used SUS304 material, pulse backflushing device, anti-static silicone rubber hose; 4. In the production process, a large amount of powder should not be attached to the pot wall and the lid of the wet granulator, and there is no dead angle mixed; 5. The particle size distribution is narrow, the uniformity is good, and the reproducibility between batch and batch is good. 6. The opening and closing of the lid on the pot body needs to be realized manually, and the opening method is the spring assist opening method. 7. The cover is equipped with a position detecting device (safety protection function). When the cover is not in the closed position, the shredder cannot be started. When the work is opened, the device is automatically stopped. 8. The granule of the granulator and the O-ring of the cover are sealed. The cylinder cover is not less than the following functional openings: observation mirror (with silicone scraper cleaning mirror and 24 volt cold light source), feed port, Adhesive feeding port, cleaning port, breathing port (the breathing port should be provided with a filtering device, using a 5 micron filter cloth); 9. The stirring paddle adopts the bottom driving method to stir the slurry shape “tangential type†to ensure that the material is spirally three-dimensionally moved in the material pot; 10. Stirring paddle and chopping knife are driven by Siemens frequency converter. The granulation process can control multi-speed and automatically jump to meet the granulation process requirements of different drugs. 11. The speed of the mixer, the speed of the cutting knife and the speed of the granulator can meet various process requirements; the gap between the stirring blade and the bottom is guaranteed to be between 0.5mm and 1.0mm; 12. The distance between the main agitating paddle blades and the side of the pot is reasonable. Within 2mm, a film cannot be formed on the side to affect the granulation effect. 13. The granulating cutter shaft and the main agitating slurry seal adopt mechanical seal and gas seal method. The gas seal and the cutter are interlocked, that is, when there is no gas or the air pressure is insufficient, the cutter cannot rotate. 14, stirring slurry speed / power, it is recommended: 50 ~ 145rpm, the driving power is not less than 55kw. Cutting knife speed / power, it is recommended: 0 ~ 3000rpm, the driving power is not less than 15kw. Wet granulator speed / power, recommended: 300 ~ 960rpm, drive power is not less than 5.5kw (should meet the needs of traditional Chinese medicine preparations). The above speed can be set by the display control, and can be automatically jumped in steps. The accuracy of the stirring paddle, the granulating knife and the whole knife speed display should be within ±2% of the actual value; the mixing time and granulation time should be displayed. accurate. 15. The mixing paddle and chopping knife can be disassembled and cleaned, and the special lifting of the paddle paddle can be easily disassembled to reduce the labor intensity. 16. The cutting blade can adjust the number of blades, and the number of cutters can be adjusted according to different varieties. 17. The mixing efficiency requirement can reach 1:0.0009 and the material can be evenly mixed. 18. Adhesive addition system, continuous feeding with positive pressure, conveying capacity 5～10Kg/min, the parts of the spray gun used for adding adhesive should be composed of nozzle, spray gun tube and spray gun fixing device, and the spray gun tube is fixed by the spray gun fixing device. On the cylinder head, the installation height is adjustable and has a scale indication, and the nozzle angle can be rotated with the barrel to adjust the proper installation angle; 19. The effective storage volume of the slurry storage tank is 120L. It has a pneumatic stirring function. The top is equipped with a tank cover, through which the slurry can be added into the tank. Supporting feeding hoses, valves, etc. The welding support on both sides of the tank body is connected with the pulp supply truck. The slurry truck is made of round tube welding and polishing, and is equipped with a universal wheel with brake for convenient movement. Can be used with fluidized bed tank equipment. 20, using a tapered screen granulator, the screen can be easily replaced; the shape of the rotor is conducive to wet granulation, and the gap between the screen and the screen can be adjusted; the feed and outlet sealing butt, the way of the discharge port is beneficial Gravity cutting; wet granulator has in-position detection function, wet granulation and wet granulator have interlocking control; 21. Lubrication requirements: Lubricants meet GMP requirements, and a list of lubricant types and equipment lubrication points is required. 22. The outer surface of the frame is made of SUS304 (0Cr18Ni9Ti) stainless steel plate with thickness d=1.5mm. The surface is smooth and easy to clean. The parts with maintenance requirements are not exposed screws or detachable covers. 23. The bearing frame is welded by channel steel and steel plate. The bottom of the frame is 304 stainless steel square tube to avoid the rust in the humid environment. At the same time, according to the structure and strength requirements, the corresponding part of the steel plate inside the frame must be strengthened to improve the rigidity of the fuselage and ensure sufficient seismic performance. 24, connecting the stairs and the fuselage, the upper surface is welded with stamped stainless steel plate, the outer surface of the motor is closed with SUS304 stainless steel plate cover, and the suspended side is made of 304 stainless steel round pipe handrail to ensure safety. 25, WIP online automatic cleaning, not less than the following cleaning points: wet cylinder body, wet method outlet, under the grain machine. The cleaning ball is selected from the German Nobel or American Spree brand. 26, the system of each unit equipment uses human-machine interface operating system, the control part uses Siemens S300 series PLC + color touch screen. 27, the equipment can be operated manually or automatically, the batch record printing includes the printer; 28. A complete batch record includes the following important parameters, but is not limited to these: 1) equipment number, 2) product name, 3) production lot number, 4) production date, 5) operator (identification number), 6) Wet granulation process records, product information and set parameters. 7) All faults and alarms, 8) Data should be able to be stored in PDF and EXCELL for future tracking and analysis. 29, with automatic fault diagnosis system: can alarm the power, voltage, motor and other abnormal conditions appearing during the operation, while the host linkage protection and stop mechanism granular system can have the following self-control settings. Fault detection module: The device can display the fault code after detecting the fault, generate alarm and interlock parking (including emergency stop, power failure, insufficient air pressure, agitation cutting fault, and the cover is not closed). Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed. Polyhydroxyalkanoates Phas,Bacterial Fermentation Pha,Elastomeric Materials Pha,Pha Suture Fasteners Xingbang High Molecular Materials Co., Ltd. , https://www.chemicaladditive.com