Release date: 2017-11-03 Recently, a news report that "stem cells help 4-year-old boys fight rare immune disorders" has received international attention. Thanks to experimental stem cell injection, the 4-year-old boy is currently recovering [1]. Today we will share this delightful case. How far is it to achieve “once and for all� If it's not a moving wheel-type infusion stand, Jovon Moss looks no different than the other 4-year-old boys. However, six months ago, the boy was diagnosed with a rare immune deficiency. From the initial flu cough, fatigue to later epilepsy, tumors blocked the airway, he nearly died. After diagnosis, 4-year-old Jovon was diagnosed with X-linked lymphocyte proliferation syndrome. This is a hereditary disease with a probability of only one in a million, and patients are extremely susceptible to EB virus infection. Jovon’s medical journey began in September last year. Also at that time, Jovon's mother noticed his cough and exhaustion for the first time. When I first went to the hospital, the doctor thought he might have been infected with the virus. However, despite receiving treatment, his "virus" did not disappear, but it became even worse. One week later, Jovon returned to the hospital to see him again, and this time he was placed in the ICU because of the EB virus infection. After spending a few weeks in a coma, he began to have seizures. After three weeks of recovery, Jovon recovered to a certain extent in November last year and was taken home. But his mother realized that Jovon's urine was still dark brown and the whole person was sleepy. However, what his mother did not realize at the time was that this genetic disease meant that Jovon's immune system could not respond to the latent Epstein-Barr virus. Jovon's condition began to get worse, his weight continued to drop, and he developed pneumonia. The energetic, toddler 4-year-old boy began to sleep, and when he was awake, his eyes could not concentrate on anything. In January of this year, Jovon was admitted to hospital for acute pneumonia. This time, his symptoms have deteriorated significantly. Until the end of January, he was admitted to the Miami Jackson Memorial Hospital because of possible immune disorders. At this point, the boy weighed only 20 pounds, could not walk, could not eat, could not speak... The doctor conducted some immunoassays on Jovon and finally diagnosed X-linked lymphocyte proliferation syndrome (XLP) this spring. His lymph nodes began to enlarge, and his neck grew so large that he blocked a half of the tracheal tumor. The situation was very bad. Stem cell therapy, giving 4 year old boys a new life machine In May of this year, Jovon and his family came to the Sylvester Comprehensive Cancer Center, and at the Sylvester Children's Clinic, Jovon quickly received a four-month chemotherapy to eliminate the tumor. To fight the infection, Jovon's attending doctor and immunologist Gary Kleiner applied to the FDA for a new stem cell treatment to supplement the T cell supply. Fortunately, this application was quickly approved by the FDA. At the end of August this year, Jovon's chemotherapy period was over. His weight began to return to normal, and the state of the whole person also recovered. This week, Jovon's body recovered very clearly. On the eve of Halloween, he was happy to travel in the hospital while receiving immunoglobulin therapy. The entire immunoglobulin injection took more than three hours, so the nurse gave him a pumpkin, and Jovon was completely immersed in the joy of Halloween... Dr. Kleiner said the next step in treatment is bone marrow transplant and is scheduled to be completed next month. "Stem cell transplantation still has a long way to go, and we are very happy that this family has made a choice." Conclusion X-linked lymphocyte proliferation syndrome (XLP) is a rare, complex primary immunodeficiency in which patients usually die early. Currently, allogeneic hematopoietic stem cell transplantation is the only way to cure this disease. As early as twenty years ago, the International Journal of Blood Transfusion and Hematology reported the experience of 7 cases of XLP in allogeneic hematopoietic stem cell transplantation in the world [2]. These experiences show the potential of stem cell transplantation to treat this rare disease. . Jovon's treatment, once again, tells people that stem cells are a very promising technology. Looking forward to the future stem cells will bring a bigger gospel to this 4-year-old boy. Reference material Stem cell therapy combats rare immune disorder in 4-year-old boy 2. Allogeneic hematopoietic stem cell transplantation for X-linked lymphoproliferative disorders (XLP): report from the International XLP Registry, International Journal of Blood Transfusion and Hematology, 1997 (2) Source: Boya stem cells (micro signal benboyalife) Time Attendance,Time Attendance Software,Face Recognition Attendance,Card Recognition Time Attendance Chongqing Huifan Technology Co., Ltd , https://www.huifantech.com