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New nanoparticles for the treatment of lung cancer go smoothly into the next stage of preclinical trials
Recently, researchers from Thomas Jefferson University said that non-small cell lung cancer nanoparticle therapy has successfully passed the next stage of preclinical testing, and the results of the study were published in the international journal Molecular Pharmaceutics.
Non-small cell lung cancer (NSCLC) is one of the most common types of lung cancer, which is often very difficult to treat; the 5-year survival rate of patients with grade 3A tumors is only 36%. In the article, researchers have developed a new type based on nanotechnology. Lung cancer treatment, researchers have now been able to use this method to effectively treat lung cancer mouse models. The nanoparticles involved in the researcher are able to transport specific molecules to block tumor growth, and at the same time promote tumors to become more sensitive to chemotherapy. This special molecule is called microRNA 29b, but if the molecule is injected alone for treatment, It may not be possible to bring effective therapeutic effects to the mouse model, and the molecule can also be rapidly degraded or removed by immune cells in the body's blood.
In order to be able to circumvent some of the research shortcomings, the researcher Sunday Shoyele and colleagues developed a new four-part nanoparticle, first of which is immunoglobulin G, which hides particles from the immune system, and then researchers An antigen called MUC1 was added, which behaves like a navigation system, and can guide nanoparticles into the lung tumor covering MUC1. Finally, the researchers used a sticky polymerization called poloxamer-188 (poloxamers-188). The microRNA 29b is combined with the other two components.
Researchers Shoyele and colleagues have shown that these components can form a spherical nanoparticle that can help find lung tumors in a mouse model of lung cancer while reducing tumor size in the model. Shoyele said the study is an extension of this previous work, and now these special nanoparticles can promote tumor tissue shrinkage in culture dishes, while also functioning in more complex living systems.
The researchers said that the technology needs additional testing before it can be used in human clinical trials. The next step is to continue to conduct in-depth research to conduct more toxicity tests, while optimizing the nanoparticle manufacturing process so that it can be successfully accessed later. In clinical trials.