Release date: 2006-08-30 Treatment of plaque psoriasis psoralen UV A is better than narrow wave UV B Red Kidney Beans,Dried Red Kidney Beans,Dark Red Kidney Beans,Small Red Kidney Beans COFCO HEBEI INTERNATIONAL TRADING CO., LTD. , https://www.cofcohb.com
Yones and others at King's College London found that for plaque psoriasis, psoralen UVA (PUVA) is better than narrow-wave UVB (NB-UVB). [Arch Dermato 2006, 142(7): 836]
To compare the efficacy of PUNA and NB-UVB in chronic plaque psoriasis, Yons et al conducted a randomized, double-blind, controlled study. A total of 93 patients were included in the study, of which 71 were of type I to IV and 17 were of type V to VI. Patients were randomized into two groups and given weekly PUVA or NB-UVB treatment with a starting dose of 70% minimum phototoxicity or minimal erythema, with a 20% increase in dose. Treatment continued until lesions were eliminated, up to 30 treatments, and the healed patients were followed for 12 months or until relapse. The main outcome evaluation indicators included the rate of cure (lesion clearance), the number of treatments, and the proportion of those who did not relapse after 6 months of cure.
The results showed that the cure rate (24%) of patients with skin type V-VI was lower than that of type I-IV (75%, P=0.001). PUVA was more effective than NB-UVB in patients with skin type I to IV. The cure rates in the PUVA group and the NB-UVB group were 84% and 65%, respectively (P=0.02). The median values ​​were 17.0 and 28.5, respectively (P < 0.001). Six months after discontinuation of treatment, 68% of patients in the PUVA group were still in remission, compared with 35% in the NB-UVB group; the average time to recurrence in the PUVA group was 8 months, and in the NB-UVB group was 4 months. (P=0.03).
Research suggestion: Although there are deficiencies in PUVA treatment, such as may cause nausea, total irradiation more than 160 ~ 200 times will increase the incidence of non-melanoma skin tumors, need to protect the eyes during treatment, need oral psoralen before irradiation Etc. However, compared with NB-UVB treatment, the therapy is more effective, the patient's symptom relief lasts longer, and the average number of treatments is less. Therefore, PUVA can still be selected for the appropriate patient.
Source: China Medical Tribune