On May 11th, at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences in Beijing, Researcher Xu Zhiheng explained to the media the results of research on Zika virus infection that directly led to microcephaly.

On May 11, a researcher at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences in Beijing showed images of neural stem cells from mammalian mice infected with Zika virus.

On May 11th, at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences in Beijing, Professor Xu Zhiheng (right) and Professor Qin Chengfeng explained to the media that Zika virus infection directly led to microcephaly.

On May 11th, at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Professor Xu Zhiheng (left) and Professor Qin Chengfeng explained their research findings and work experience to the media.

Since mid-2015, Zika virus infection has spread in South America and spread around the world. China has found many cases of Zika virus infection, so it is also exposed to the risk of import and cause epidemics. Compared with the previous milder conditions, the 2015-2016 outbreak of the Americas was particularly worthy of caution. When the Zika virus broke out in Brazil, a large number of babies with microcephaly suddenly appeared. From March 2015 to March 2016, more than 5,000 babies in Brazil were diagnosed with microcephaly, which was 20 times higher than in previous years, and most of the mothers of these babies were infected with Zika virus. In view of the seriousness of the virus in the world, and the upcoming Olympic Games in Brazil, the International Health Organization (WHO) announced that Zika virus infection is a “public health emergency of international concern”. At present, many research institutions around the world are redoubled efforts to confirm the association between infantile microcephaly and pregnant women infected with Zika virus.

Microcephaly is a rare disease in which the baby develops abnormally in the uterus or infancy, resulting in a markedly smaller head. Infants with microcephaly have obvious abnormal brain development during their growth and development, and their mental development is significantly slow. Some children may experience convulsions, stiff limbs or swaying of hands and feet.

The research team of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the research team of the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences, Qin Chengfeng, worked together for the first time to establish a small animal model of Zika virus and confirmed that Zika virus can directly cause microcephaly. happened. They found in mammalian mice that Zika virus can rapidly replicate in the embryonic brain and infect neural stem cells, causing abnormal proliferation and differentiation of neural stem cells, and a large number of neuronal deaths. Eventually lead to thinning of the cerebral cortex and microcephaly. Through genome-wide expression profiling, they found that a large number of genes associated with immune, microcephaly, Zika virus potential receptors and apoptosis were abnormally abnormal. This study not only provides the first animal model to study the microcephaly caused by Zika virus, but also lays a good foundation for further study of the pathogenic mechanism and related treatment of Zika virus.

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