The scientific name is Geinula jacobsoni Ogloblin, Coleoptera. Alias ​​green winged short sheath Gecko. Distributed in Qinghai, Sichuan and Tibet. Host larvae damage wheat and grass weeds, adults do not eat grass crops. The traits are characterized by larvae rushing into the root stem section of the wheat seedlings that is in the stage of tillering, and feeding on the inner wall tissue of the tender stem, causing the damaged seedlings to turn grayish green, dead in the heart of the seedlings, thickened at the base of the leaves, and often become a group or a victim. The marginal victim was heavy and caused the lack of seedlings for wheat and barley. Morphological characteristics Adult body length 3.5-6mm, width 1.9-2.5mm, metamorphosis of adult emergence feathers, 6-8 hours after emergence of elytra is golden green, more than 24 hours into black, pronotum tan. The tentacles are thick. Section 3 is longer than section 2. Section 4 is longer than section 3. Sections 1-7 are tan, and sections 8-11 are black. The head has a deep ditch with a slightly enlarged upper lip, a deep depression in the middle of the front edge, a flattened antennae, a smooth frontal tumor, a flat top, a thickly engraved and short-lying hair, and a border around the prosthodontic plate; The area has 3 indentations; the base of the scutellum is wider and the ends are narrower; the cobwebs are leathery, with thick stripes and short hairs, the engraved points are thick, and the shoulders are prominent. Short and thick. The male end of the abdomen has a wide concave cut in the middle of the abdomen, and the female has a flat cut in the middle of the abdomen. The final larvae have a body length of 9.8-11.8 mm. The newly hatched larvae are dark gray to yellow. Head, thoracodorsal plate, buttocks plate dark brown, hard texture. The back of the middle section has dark brown spots of different sizes and shapes. Tail knobs with 2 knobs. Bare beak 0.3-0.5mm long, colostrum white, after changing bright yellow to golden yellow. Living habits Baiyu County, Sichuan Province, 1 generation old, the eggs in the soil overwintering, the egg period is an average of 279 days, adults in each year from late July to late August spawning, hatching in late April to early June, larvae From late June to late September, it takes nine to 18 days. Adults die 3-15 days after spawning. Adults 17-68 days. Adults have a habit of feeding on clusters. They like to eat on Ai, Leng, skunk, and oysters within 40m of the Tianbian. There is a clustered shift to harmful habits and there is a false death. The females grow rapidly, and it takes 5-7 minutes for females and males to complete one time. The insect's hind wings are degraded and unable to fly, mainly relying on crawling, and their range of activities is small. The number of eggs laid is 14-140 eggs. Control methods (1) When the adult does not spawn at the feeding stage, spray 2.5% dichlorfon 2000 times or 5% chlorimethanol 2000 times, 5% lefroling 3000 times, 20% chrysanthemum Emulsion 1500 times, 21% kill quail EC 3000 times. (2) In the place where the marginal victim of the severely-damaged wheat field in the previous year was heavy, 3% Yingbidan granules or 3% methylisofluthiin granules or 4.5% Aldolescent powder was sprayed out, and 3kg per 667m2 was used to mix fine soil. 20 to 30kg, sow on the soil before sowing, then plough or hoe. (3) Removal of weeds in the field and eradication of weeds such as cockroaches and maggots within 50 m of the marginal diameter of the plot, and cutting off the adult food source is also an effective agricultural control method. Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
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Palbociclib Intermediates,Cas 571188-59-5,Cas 1013916-37-4,Cas 1016636-76-2 Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
It was reviewed and approved under the Food and Drug Administration`s (FDA) accelerated Priority Review and Breakthrough Therapy designation programs on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor positive advanced breast cancer.
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