Release date: 2007-10-16 Hypoxia-induced expression and activation of AMPK in rat dental pulp cells Blood Plasma Products,Blood Products,Human Rabies Immunoglobulin,Viral Infection Sichuan Yuanda Shuyang Pharmaceutical Co., Ltd. , https://www.syimmunoglobulin.com
AMP-activated protein kinase (AMPK) is a stress-responsive enzyme involved in cellular energy stress. Fukuyama Y and colleagues at the Tokyo School of Stomatology in Japan speculated that hypoxia inhibits oxidative phosphorylation and ATP production, thereby activating AMPK to protect cells. Researchers studied the effects of hypoxia on cell proliferation, the expression of AMPK and hypoxia-inducible factor 1α (HIF-1α), and the activation of AMPK in rat dental pulp RPC-C2A cells, and explored the expression of AMPK and HIF-1α. The relationship between. The results show that AMPK in this type of cells consists of the catalytic subunit α1 and the regulatory subunits β1 and γ1. Cell proliferation was initially inhibited by hypoxia, but subsequent proliferation was evident with increased expression of AMPK and HIF-1α and activation of AMPK. Down-regulation of AMPKα1 by siRNA inhibited cell proliferation under normoxia and hypoxia. Fukuyama et al concluded that although the expression of HIF-1α was not affected under hypoxic conditions, induction and activation of AMPK were essential for cell proliferation. ——Midi Medical Network