GMP Certified Metformin Hydrochloride Tablet 500mg

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Model NO.: 500mg
Standard: USP
OEM: Available
Shelf Life: 3 Years
Trademark: Sundent
Transport Package: 10tabs/Blister
Specification: 500mg
Origin: China
HS Code: 3004909099
Model NO.: 500mg
Standard: USP
OEM: Available
Shelf Life: 3 Years
Trademark: Sundent
Transport Package: 10tabs/Blister
Specification: 500mg
Origin: China
HS Code: 3004909099
Description
Metformin hydrochloride tablet 500mg

Ingredients

The main component of this product is metformin hydrochloride. Its chemical name is: 1.1-dimethylbiguanide hydrochloride.
Chemical Structure:

Molecular Formula: C4H11N5·HCl
Molecular weight: 165.63
Character 
This product is sugar-coated or film-coated, after removing the coating was white.
Indications
For people with type 2 diabetes who are not satisfied with simple diet control, especially those with obesity and hyperinsulinemia, this medicine not only has hypoglycemic effect, but also may have the effect of reducing body weight and hyperinsulinemia. For some patients with poor efficacy of sulfonylureas can be effective, such as with sulfonylureas, small intestine glycosidase inhibitors or thiazolidinedione hypoglycemic drugs combined, more effective than single use alone. It can also be used in patients with insulin therapy to reduce insulin use.
Specification 
0.5g
Dosage
Oral adult 0.25g once a day, 2-3 times a day, then gradually increase the amount according to the effect, the general daily dose of 1 ~ 1.5g up to no more than 2g daily. Meal or immediate after meals, can reduce the gastrointestinal reaction .
Adverse reactions
1. Common are: nausea, vomiting, diarrhea, metallic taste in the mouth.
2. Sometimes fatigue, tiredness, dizziness, rashes.
3. Although the incidence of lactic acidosis is very low, it should be noted. The clinical manifestations are vomiting, abdominal pain, hyperventilation, mental disturbance, increased blood lactate concentration and cannot be explained by uremia, ketoacidosis, or salicylate poisoning.
4. It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce erythrocytic anemia, and can also cause malabsorption.
Contraindication
The following conditions should be disabled:
1.Type II diabetes is associated with ketoacidosis, liver and renal insufficiency (blood creatinine exceeding 1.5mg/dl), pulmonary insufficiency, heart failure, acute myocardial infarction, severe infection and trauma, major surgery, and clinically low Blood pressure and hypoxia.
2. Diabetes with severe chronic complications (such as diabetic nephropathy, diabetic retinopathy).
3. Before the foot vein pyelogram or arteries make color.
4. Alcoholics.
5. Severe heart and lung disease patients.
6. Vitamin B12, folic acid and iron deficiency patients.
7. Patients with poor general condition (such as malnutrition, dehydration).
Precautions
1.Type I diabetes should not be used alone (can be combined with insulin);
2. Frequently check the fasting blood glucose, urine sugar and urine ketone body during the medication, and regularly measure the serum creatinine and blood lactate concentration.
3. Those who have previous history of lactic acidosis should be used with caution.
4. When combined with insulin therapy, prevent hypoglycemia.
Storage
Keep it sealed.

Product foto
GMP Certified Metformin Hydrochloride Tablet 500mg


Our factory
This product is produced in our GMP factory, all our facility has past China GMP, and also officially certificated by more than ten countries' MOH. 
GMP Certified Metformin Hydrochloride Tablet 500mg



Our Service
We can specially develop the products per customers' specification.
We can offer OEM service with customers' private brands and labels.
We can offer excellent after-sale service and professional technical support.


Our Quality control system
In manufacturing, quality is what sustains our life.  Starting from the material selection, there are many factors that contribute to the quality control process.  Our manufacturing facility is GMP certified. Quality Control (QC) and monitoring procedures are built into every aspect of our work.
Our Quality Control System is outlined below:
  1. Initial inspection (such as raw material, excipients, package materials, etc.)
  2. In-process inspection (make sure that each testing items should be qualified )
  3. Final inspection before shipment of each order. 
  4. Provide temperature control recorder when it is necessary for special market before loading.

Our Registration Team and technical support
We have experienced team to provide qualified and professional registration documents for most of countries. Up to present, we have registered more than hundred products and exported to more than 20 countries. Especially including those in Asia, Africa, South America, Middle east area and East Europe.
We can provide regulatory documents
    1. GMP Certificate / CE Certificate
    2. Free sales certificate 
    3. Certificate of Pharmaceutical Products
    4. Manufacture License
    5. CTD Dossier.
Description
Metformin hydrochloride tablet 500mg

Ingredients

The main component of this product is metformin hydrochloride. Its chemical name is: 1.1-dimethylbiguanide hydrochloride.
Chemical Structure:

Molecular Formula: C4H11N5·HCl
Molecular weight: 165.63
Character 
This product is sugar-coated or film-coated, after removing the coating was white.
Indications
For people with type 2 diabetes who are not satisfied with simple diet control, especially those with obesity and hyperinsulinemia, this medicine not only has hypoglycemic effect, but also may have the effect of reducing body weight and hyperinsulinemia. For some patients with poor efficacy of sulfonylureas can be effective, such as with sulfonylureas, small intestine glycosidase inhibitors or thiazolidinedione hypoglycemic drugs combined, more effective than single use alone. It can also be used in patients with insulin therapy to reduce insulin use.
Specification 
0.5g
Dosage
Oral adult 0.25g once a day, 2-3 times a day, then gradually increase the amount according to the effect, the general daily dose of 1 ~ 1.5g up to no more than 2g daily. Meal or immediate after meals, can reduce the gastrointestinal reaction .
Adverse reactions
1. Common are: nausea, vomiting, diarrhea, metallic taste in the mouth.
2. Sometimes fatigue, tiredness, dizziness, rashes.
3. Although the incidence of lactic acidosis is very low, it should be noted. The clinical manifestations are vomiting, abdominal pain, hyperventilation, mental disturbance, increased blood lactate concentration and cannot be explained by uremia, ketoacidosis, or salicylate poisoning.
4. It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce erythrocytic anemia, and can also cause malabsorption.
Contraindication
The following conditions should be disabled:
1.Type II diabetes is associated with ketoacidosis, liver and renal insufficiency (blood creatinine exceeding 1.5mg/dl), pulmonary insufficiency, heart failure, acute myocardial infarction, severe infection and trauma, major surgery, and clinically low Blood pressure and hypoxia.
2. Diabetes with severe chronic complications (such as diabetic nephropathy, diabetic retinopathy).
3. Before the foot vein pyelogram or arteries make color.
4. Alcoholics.
5. Severe heart and lung disease patients.
6. Vitamin B12, folic acid and iron deficiency patients.
7. Patients with poor general condition (such as malnutrition, dehydration).
Precautions
1.Type I diabetes should not be used alone (can be combined with insulin);
2. Frequently check the fasting blood glucose, urine sugar and urine ketone body during the medication, and regularly measure the serum creatinine and blood lactate concentration.
3. Those who have previous history of lactic acidosis should be used with caution.
4. When combined with insulin therapy, prevent hypoglycemia.
Storage
Keep it sealed.

Product foto
GMP Certified Metformin Hydrochloride Tablet 500mg


Our factory
This product is produced in our GMP factory, all our facility has past China GMP, and also officially certificated by more than ten countries' MOH. 
GMP Certified Metformin Hydrochloride Tablet 500mg



Our Service
We can specially develop the products per customers' specification.
We can offer OEM service with customers' private brands and labels.
We can offer excellent after-sale service and professional technical support.


Our Quality control system
In manufacturing, quality is what sustains our life.  Starting from the material selection, there are many factors that contribute to the quality control process.  Our manufacturing facility is GMP certified. Quality Control (QC) and monitoring procedures are built into every aspect of our work.
Our Quality Control System is outlined below:
  1. Initial inspection (such as raw material, excipients, package materials, etc.)
  2. In-process inspection (make sure that each testing items should be qualified )
  3. Final inspection before shipment of each order. 
  4. Provide temperature control recorder when it is necessary for special market before loading.

Our Registration Team and technical support
We have experienced team to provide qualified and professional registration documents for most of countries. Up to present, we have registered more than hundred products and exported to more than 20 countries. Especially including those in Asia, Africa, South America, Middle east area and East Europe.
We can provide regulatory documents
    1. GMP Certificate / CE Certificate
    2. Free sales certificate 
    3. Certificate of Pharmaceutical Products
    4. Manufacture License
    5. CTD Dossier.